Name              Trade Name                             Generic Name

                        Letairis                         Ambrisentan

Use                  Treat pulmonary hypertension

Action             Letairis blocks the effects of endothelin, which is a natural substance in the body that causes narrowing or constriction of blood vessels.  Blocking the effects of endothelin helps to prevent the abnormal constriction of the pulmonary artery vessels

Every drug is capable of producing side effects.  Most patients experience no, or minor, side effects.  Possible side effects:

Inflammation of throat and nasal passages

Swelling of the legs and ankles

Palpitations (irregular heart beats)

Anemia

Nasal congestion

Low blood pressure

Headache

Flushing

Fatigue

Itching

Constipation

Shortness of breath

May be taken with or without food

Take your medication once daily at the same time each day

Do not split, crush or chew the tablet

If you take more than the prescribed dose, call your doctor

If a dose is missed, do not take a double dose

Do not stop this medication unless directed by your doctor or nurse

Check your blood pressure regularly at home

Speak to your doctor if you are pregnant or are planning to become pregnant

Breastfeeding is not recommended while taking this medication

Blood test to check liver function and hemoglobin is required prior to starting this medication and monthly throughout the use of it.